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Event Title

HMG-CoA reductase, Inhibition

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
HMG-CoA reductase inhibition leading to decreased fertility MIE

Chemical Initiators

The following are chemical initiators that operate directly through this Event:

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

The activity of HMG-CoA reductase inhibition may be measured by a commercially available kit which measures a decrease in absorbance at 340 nm, which represents the oxidation of NADPH by the catalytic subunit of HMGR in the presence of the substrate HMG-CoA. Sterol Regulatory element-binding factor 1 (SREBF) is the transcription factor controlling downstream regulation of HMG-CoA reductase. The ToxCast assay ATG_SREBF1_CIS_up is one method of measuring transcriptional control of HMG-CoA reductase.

Evidence Supporting Taxonomic Applicability