Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|HMG-CoA reductase inhibition leading to decreased fertility||MIE|
The following are chemical initiators that operate directly through this Event:
Level of Biological Organization
How this Key Event works
How it is Measured or Detected
The activity of HMG-CoA reductase inhibition may be measured by a commercially available kit which measures a decrease in absorbance at 340 nm, which represents the oxidation of NADPH by the catalytic subunit of HMGR in the presence of the substrate HMG-CoA. Sterol Regulatory element-binding factor 1 (SREBF) is the transcription factor controlling downstream regulation of HMG-CoA reductase. The ToxCast assay ATG_SREBF1_CIS_up is one method of measuring transcriptional control of HMG-CoA reductase.