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Event Title

Embryolethality, Increase

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Aryl hydrocarbon receptor activation leading to embryolethality via cardiotoxicty AO [[Aop:150#Essentiality of the Key Events|]]

Taxonomic Applicability

Name Scientific Name Evidence Links

Affected Organs

Synonym Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

Embryo death at any stage in development prior to birth/hatch is considered embryolethal. In birds and fish it may be identified as failure to hatch or lack of movement within the egg when candled; heartbeat monitors are also available for identifying viable avian eggs. In mammals, stillborn or mummified offspring, or an increased rate of resorptions early in pregnancy are all considered embryolethal.

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability