Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|Oxidative Stress Leading to Hypertension||KE||Strong|
|Homo sapiens||Homo sapiens||Strong||NCBI|
|Rattus norvegicus||Rattus norvegicus||Weak||NCBI|
Level of Biological Organization
How this Key Event works
Vascular resistance is the resistance to blood flow in the circulatory system (Siddiqui, 2011). Systemic vascular resistance (SVR), also known as total peripheral resistance, refers specifically to the resistance to blood flow offered by the peripheral circulation. Vasodilation decreases SVR while vasoconstriction or impaired vasodilation increases SVR.
How it is Measured or Detected
Vascular resistance cannot be measured by any direct means, but can be calculated using a formula: (mean arterial pressure minus mean right arterial pressure) divided by cardiac output.
Evidence Supporting Taxonomic Applicability
Increased SVR was observed in humans and rats.
Siddiqui, A. (2011). Effects of Vasodilation and Arterial Resistance on Cardiac Output. J. Clin. Exp. Cardiol. 02.