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Event Title

Vascular Resistance, Increase

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Oxidative Stress Leading to Hypertension KE Strong

Taxonomic Applicability

Name Scientific Name Evidence Links
Homo sapiens Homo sapiens Strong NCBI
Rattus norvegicus Rattus norvegicus Weak NCBI

Level of Biological Organization

Biological Organization

How this Key Event works

Vascular resistance is the resistance to blood flow in the circulatory system (Siddiqui, 2011). Systemic vascular resistance (SVR), also known as total peripheral resistance, refers specifically to the resistance to blood flow offered by the peripheral circulation. Vasodilation decreases SVR while vasoconstriction or impaired vasodilation increases SVR.

How it is Measured or Detected

Vascular resistance cannot be measured by any direct means, but can be calculated using a formula: (mean arterial pressure minus mean right arterial pressure) divided by cardiac output.

Evidence Supporting Taxonomic Applicability

Increased SVR was observed in humans and rats.


Siddiqui, A. (2011). Effects of Vasodilation and Arterial Resistance on Cardiac Output. J. Clin. Exp. Cardiol. 02.