Event:970

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Event Title

Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs, Decreased LH release from Anterior Pituitary

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats KE Moderate

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

References