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Event Title

Suppression of transplant rejection, Suppression

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression AO [[Aop:154#Essentiality of the Key Events|]]

Taxonomic Applicability

Name Scientific Name Evidence Links

Affected Organs

Synonym Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

In kidney transplant recipients, the administration of FK506 suppresses acute rejection and maintains favorable conditions for graft survival and function (Pirsch et al. 1997, Sonoda et al. 2003, Ekberg et al. 2007, Ekberg et al. 2009). Also, in recipients of liver, kidney, heart, pancreas, and small-intestine transplants, acute rejection was suppressed (Astellas Pharma Inc. 2014).

How it is Measured or Detected

Evidence Supporting Taxonomic Applicability