Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression||AO||[[Aop:154#Essentiality of the Key Events|]]|
Level of Biological Organization
How this Key Event works
In kidney transplant recipients, the administration of FK506 suppresses acute rejection and maintains favorable conditions for graft survival and function (Pirsch et al. 1997, Sonoda et al. 2003, Ekberg et al. 2007, Ekberg et al. 2009). Also, in recipients of liver, kidney, heart, pancreas, and small-intestine transplants, acute rejection was suppressed (Astellas Pharma Inc. 2014).