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Event Title

Relief of atopic dermatitis, Relief

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression AO [[Aop:154#Essentiality of the Key Events|]]

Taxonomic Applicability

Name Scientific Name Evidence Links

Affected Organs

Synonym Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

Patients with atopic dermatitis who were treated with FK506 ointment for a period of one year enjoyed relief from skin damage (FK506 Ointment Study Group. 1998). Generally, the skin of patients with atopic dermatitis has a higher expression of TLR-1 and a lower expression of TLR-2 than that of healthy subjects, but application of FK506 ointment suppressed expression of TLR-1 and increased expression of TLR-2 (Antiga et al. 2011).

How it is Measured or Detected

Evidence Supporting Taxonomic Applicability