Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression||AO||[[Aop:154#Essentiality of the Key Events|]]|
Level of Biological Organization
How this Key Event works
Patients with atopic dermatitis who were treated with FK506 ointment for a period of one year enjoyed relief from skin damage (FK506 Ointment Study Group. 1998). Generally, the skin of patients with atopic dermatitis has a higher expression of TLR-1 and a lower expression of TLR-2 than that of healthy subjects, but application of FK506 ointment suppressed expression of TLR-1 and increased expression of TLR-2 (Antiga et al. 2011).