Key Event Overview
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AOPs Including This Key Event
|AOP Name||Event Type||Essentiality|
|The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression||AO||[[Aop:154#Essentiality of the Key Events|]]|
Level of Biological Organization
How this Key Event works
Complications from infection as a side-effect of administering FK506 was found to be similar to that of cyclosporin A (Ekberg et al. 2007), and recipients of liver transplants treated with FK506 were found to have suffered bacterial, viral, and fungal infections (Alessiani et al. 1991, Fung et al. 1991).