Relationship:1027

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Key Event Relationship Overview

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Description of Relationship

Upstream Event Downstream Event/Outcome
Triiodothyronine (T3) in serum, Decreased Posterior swim bladder inflation, Reduced

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Directly Leads to
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Directly Leads to

Taxonomic Applicability

Name Scientific Name Evidence Links
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

How Does This Key Event Relationship Work

Weight of Evidence

Biological Plausibility

Empirical Support for Linkage

  • Maternal injection of T3, resulting in increased T3 concentrations in the eggs of striped bass (Morone saxatilis) lead to significant increases in both swim bladder inflation and survival (Brown et al., 1988).

Uncertainties or Inconsistencies

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Evidence Supporting Taxonomic Applicability

References

  • Brown, C. L., Doroshov, S. I., Nunez, J. M., Hadley, C., Vaneenennaam, J., Nishioka, R. S. and Bern, H. A. (1988), Maternal triiodothyronine injections cause increases in swimbladder inflation and survival rates in larval striped bass, Morone saxatilis. J. Exp. Zool., 248: 168–176. doi: 10.1002/jez.1402480207