Relationship:1027
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Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Triiodothyronine (T3) in serum, Decreased | Posterior swim bladder inflation, Reduced |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation | Directly Leads to | ||
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation | Directly Leads to |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|---|---|---|
zebrafish | Danio rerio | NCBI | |
fathead minnow | Pimephales promelas | NCBI |
How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
- Maternal injection of T3, resulting in increased T3 concentrations in the eggs of striped bass (Morone saxatilis) lead to significant increases in both swim bladder inflation and survival (Brown et al., 1988).
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?
Evidence Supporting Taxonomic Applicability
References
- Brown, C. L., Doroshov, S. I., Nunez, J. M., Hadley, C., Vaneenennaam, J., Nishioka, R. S. and Bern, H. A. (1988), Maternal triiodothyronine injections cause increases in swimbladder inflation and survival rates in larval striped bass, Morone saxatilis. J. Exp. Zool., 248: 168–176. doi: 10.1002/jez.1402480207