Relationship:1031

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Key Event Relationship Overview

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Description of Relationship

Upstream Event Downstream Event/Outcome
Posterior swim bladder inflation, Reduced Anterior swim bladder inflation, Reduced

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation Directly Leads to
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation Directly Leads to

Taxonomic Applicability

Name Scientific Name Evidence Links
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

How Does This Key Event Relationship Work

Weight of Evidence

Biological Plausibility

The anterior chamber is formed by evagination from the cranial end of the posterior chamber (Robertson et al., 2007, Winata et al., 2009). Therefore it is plausible to assume that the anterior chamber cannot inflate in cases where the posterior chamber is not inflated.

Empirical Support for Linkage

Include consideration of temporal concordance here

Uncertainties or Inconsistencies

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Evidence Supporting Taxonomic Applicability

References

Robertson, G.N., McGee, C.A.S., Dumbarton, T.C., Croll, R.P., Smith, F.M., 2007. Development of the swimbladder and its innervation in the zebrafish, Danio rerio. Journal of Morphology 268, 967-985.

Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., Gong, Z., 2009. Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology 331, 222-236.