Relationship:1031
Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Posterior swim bladder inflation, Reduced | Anterior swim bladder inflation, Reduced |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation | Directly Leads to | ||
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation | Directly Leads to |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|---|---|---|
zebrafish | Danio rerio | NCBI | |
fathead minnow | Pimephales promelas | NCBI |
How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
The anterior chamber is formed by evagination from the cranial end of the posterior chamber (Robertson et al., 2007, Winata et al., 2009). Therefore it is plausible to assume that the anterior chamber cannot inflate in cases where the posterior chamber is not inflated.
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?
Evidence Supporting Taxonomic Applicability
References
Robertson, G.N., McGee, C.A.S., Dumbarton, T.C., Croll, R.P., Smith, F.M., 2007. Development of the swimbladder and its innervation in the zebrafish, Danio rerio. Journal of Morphology 268, 967-985.
Winata, C.L., Korzh, S., Kondrychyn, I., Zheng, W., Korzh, V., Gong, Z., 2009. Development of zebrafish swimbladder: The requirement of Hedgehog signaling in specification and organization of the three tissue layers. Developmental Biology 331, 222-236.