Relationship:1043

From AOP-Wiki
Jump to: navigation, search


Key Event Relationship Overview

Please follow link to widget page to edit this section.

If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.

Description of Relationship

Upstream Event Downstream Event/Outcome
Deiodinase 2, Inhibition Anterior swim bladder inflation, Reduced

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation Indirectly Leads to

Taxonomic Applicability

Name Scientific Name Evidence Links
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

How Does This Key Event Relationship Work

Weight of Evidence

Biological Plausibility

Empirical Support for Linkage

  • Exposure of fathead minnows (Pimephales promelas) to the non-specific deiodinase inhibitor iopanoic acid from 6-14 dpf resulted in impaired inflation and reduced size of the anterior swim bladder. Exposure from 6-18 dpf impacted anterior chamber size, but not inflation rates. Exposure from 6-21 dpf had no effect on anterior swim bladder inflation. Together the results suggest the inhibition of DIO2 can delay, although not necessarily prevent, anterior inflation in fathead minnows (Cavallin et al., unpublished).

Uncertainties or Inconsistencies

Only few studies have been performed, of which none have been published yet.

Quantitative Understanding of the Linkage

Evidence Supporting Taxonomic Applicability

The evidence for a relationship between DIO2 inhibition and inflation of the anterior chamber of the swim bladder currently comes from work on zebrafish and fathead minnow.

References