- 1 Key Event Relationship Overview
- 2 How Does This Key Event Relationship Work
- 3 Weight of Evidence
- 4 Quantitative Understanding of the Linkage
- 5 Evidence Supporting Taxonomic Applicability
- 6 References
Key Event Relationship Overview
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Description of Relationship
|Upstream Event||Downstream Event/Outcome|
|Antigen presentation, Generation of novel epitopes||Immune system, Sensitization|
AOPs Referencing Relationship
|AOP Name||Type of Relationship||Weight of Evidence||Quantitative Understanding|
|Adverse outcome pathway for airway irritation and chemical sensitization||Directly Leads to||Strong||Weak|
How Does This Key Event Relationship Work
Weight of Evidence
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?