Relationship:61
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Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Ca++ ATPase, Inhibition | Ca++ (intracellular), Increase |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Calcium-mediated neuronal ROS production and energy imbalance | Directly Leads to | Strong |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
The purpose of the Ca++ ATPase is to pump Ca++ out of the cell [1],[2]. When the ATPase is inhibited, this will lead to an overall increase (relative) of intracellular calcium.
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?
Evidence Supporting Taxonomic Applicability
References
- ↑ Jensen, TP; Buckby LE; Empson RM (2004). "Expression of plasma membrane Ca2+ ATPase family members and associated synaptic proteins in acute and cultured organotypic hippocampal slices from rat.". Brain Research. Developmental Brain Research. 152 (2): 129–136. doi:10.1016/j.devbrainres.2004.06.004. PMID 15351500.
- ↑ Feng, M.Y., Rao, R. 2013. New insights into store-independent Ca(2+) entry: secretory pathway calcium ATPase 2 in normal physiology and cancer.Int J Oral Sci 5(2): 71-4.