Relationship:872
From AOP-Wiki
Contents
Key Event Relationship Overview
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Thyroidal iodide uptake, Decreased | Thyroid hormone synthesis, Decreased |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals | Directly Leads to | Strong | Strong |
Inhibition of Na+/I- symporter (NIS) decreases TH synthesis leading to learning and memory deficits in children | Directly Leads to | Strong | Strong |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?