Difference between revisions of "Aop:153"

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__NOTOC__
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= Status =
{{#widget:Network}}
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<span style="color:#FF0000">
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This is a legacy representation of this AOP. Please see the current version here:
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[//{{SERVERNAME}}/aops/153 https://{{SERVERNAME}}/aops/153]
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== AOP Title ==  
 
== AOP Title ==  
 
<div id='longTitle' class='Title'> Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats </div>
 
<div id='longTitle' class='Title'> Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats </div>
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!Molecular Initiating Event
 
!Molecular Initiating Event
 
!Support for Essentiality
 
!Support for Essentiality
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|[[Event:964|Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol, Inhibition of Aromatase Enzyme]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
  
 
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!Event
 
!Event
 
!Support for Essentiality
 
!Support for Essentiality
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|-
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|[[Event:965|Reduced steroidogenic production of estradiol in granulosa cells, reduction in ovarian granulosa cells synthesis of estradiol]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
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|-
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|[[Event:966|Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation, Reduced Estradiol in Circulation]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
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|-
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|[[Event:967|Reduced estradiol in circulation decreases estrogen concentration at hypothalamus, Decreased positive estrogenic feedback on hypothalamus]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
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|-
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|[[Event:968|Decreased hypothalamic estrogen reduces kisspeptinergic neuron response , Decreased Kisspeptin release from neurons in AVPV]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
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|-
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|[[Event:969|Decreased Kisspeptin stimulation of GnRH neurons , Decreased GnRH Release]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
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|-
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|[[Event:970|Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs, Decreased LH release from Anterior Pituitary]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
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|-
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|[[Event:971|Decrease or delay in LH surge required for ovulation , Ovulation of oocytes Reduced, Delayed, or Blocked]]||[[Aop:153#Essentiality of the Key Events|Moderate]]
  
 
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!Adverse Outcome
 
!Adverse Outcome
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|[[Event:972|Reduced number of oocytes ovulated , Decreased fertility]]
  
 
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*[https://aopkb.org/common/AOP_Graphic_Template2.pptx Click to download template for graphical representation]
 
*[https://aopkb.org/common/AOP_Graphic_Template2.pptx Click to download template for graphical representation]
  
[[File:Replaced_by_image_name.jpg | 900px | Click to upload graphical representation]]
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[[File:Aop-153.jpg | 900px | Click to upload graphical representation]]
  
 
== Overall Assessment of the AOP ==
 
== Overall Assessment of the AOP ==

Latest revision as of 23:16, 11 December 2016

Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/153


AOP Title

Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
Short name: Aromatase Inhibition in Female Rats

Authors

Status

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Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

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Abstract

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Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol, Inhibition of Aromatase Enzyme Moderate

Key Events

Event Support for Essentiality
Reduced steroidogenic production of estradiol in granulosa cells, reduction in ovarian granulosa cells synthesis of estradiol Moderate
Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation, Reduced Estradiol in Circulation Moderate
Reduced estradiol in circulation decreases estrogen concentration at hypothalamus, Decreased positive estrogenic feedback on hypothalamus Moderate
Decreased hypothalamic estrogen reduces kisspeptinergic neuron response , Decreased Kisspeptin release from neurons in AVPV Moderate
Decreased Kisspeptin stimulation of GnRH neurons , Decreased GnRH Release Moderate
Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs, Decreased LH release from Anterior Pituitary Moderate
Decrease or delay in LH surge required for ovulation , Ovulation of oocytes Reduced, Delayed, or Blocked Moderate

Adverse Outcome

Adverse Outcome
Reduced number of oocytes ovulated , Decreased fertility

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

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Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.

Weight of Evidence Summary

Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.

Quantitative Considerations

Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.

Considerations for Potential Applications of the AOP (optional)

References