Difference between revisions of "Aop:153"
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+ | This is a legacy representation of this AOP. Please see the current version here: | ||
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+ | [//{{SERVERNAME}}/aops/153 https://{{SERVERNAME}}/aops/153] | ||
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== AOP Title == | == AOP Title == | ||
<div id='longTitle' class='Title'> Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats </div> | <div id='longTitle' class='Title'> Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats </div> | ||
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!Event | !Event | ||
!Support for Essentiality | !Support for Essentiality | ||
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+ | |[[Event:965|Reduced steroidogenic production of estradiol in granulosa cells, reduction in ovarian granulosa cells synthesis of estradiol]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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+ | |- | ||
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+ | |[[Event:966|Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation, Reduced Estradiol in Circulation]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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+ | |- | ||
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+ | |[[Event:967|Reduced estradiol in circulation decreases estrogen concentration at hypothalamus, Decreased positive estrogenic feedback on hypothalamus]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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+ | |- | ||
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+ | |[[Event:968|Decreased hypothalamic estrogen reduces kisspeptinergic neuron response , Decreased Kisspeptin release from neurons in AVPV]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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+ | |- | ||
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+ | |[[Event:969|Decreased Kisspeptin stimulation of GnRH neurons , Decreased GnRH Release]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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+ | |- | ||
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+ | |[[Event:970|Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs, Decreased LH release from Anterior Pituitary]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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+ | |- | ||
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+ | |[[Event:971|Decrease or delay in LH surge required for ovulation , Ovulation of oocytes Reduced, Delayed, or Blocked]]||[[Aop:153#Essentiality of the Key Events|Moderate]] | ||
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!Adverse Outcome | !Adverse Outcome | ||
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+ | |[[Event:972|Reduced number of oocytes ovulated , Decreased fertility]] | ||
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*[https://aopkb.org/common/AOP_Graphic_Template2.pptx Click to download template for graphical representation] | *[https://aopkb.org/common/AOP_Graphic_Template2.pptx Click to download template for graphical representation] | ||
− | [[File: | + | [[File:Aop-153.jpg | 900px | Click to upload graphical representation]] |
== Overall Assessment of the AOP == | == Overall Assessment of the AOP == |
Latest revision as of 23:16, 11 December 2016
Status
This is a legacy representation of this AOP. Please see the current version here:
AOP Title
Authors
Status
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This AOP page was last modified on 12/11/2016.
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Abstract
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Summary of the AOP
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Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
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Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol, Inhibition of Aromatase Enzyme | Moderate |
Key Events
Adverse Outcome
Adverse Outcome |
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Reduced number of oocytes ovulated , Decreased fertility |
Relationships Among Key Events and the Adverse Outcome
Event | Description | Triggers | Weight of Evidence | Quantitative Understanding |
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Network View
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Life Stage Applicability
Life Stage | Evidence | Links |
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Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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Sex Applicability
Sex | Evidence | Links |
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Graphical Representation
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Overall Assessment of the AOP
Domain of Applicability
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
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Weight of Evidence Summary
Summary Table
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Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.