Difference between revisions of "Aop:157"

From AOP-Wiki
Jump to: navigation, search
(Status)
 
Line 1: Line 1:
 
__NOTOC__
 
__NOTOC__
{{#widget:Revisions}}
+
= Status =
{{#widget:Network}}
+
<span style="color:#FF0000">
 +
This is a legacy representation of this AOP. Please see the current version here:
 +
 
 +
[//{{SERVERNAME}}/aops/157 https://{{SERVERNAME}}/aops/157]
 +
</span>
 +
 
 +
 
 
== AOP Title ==  
 
== AOP Title ==  
 
<div id='longTitle' class='Title'> Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation  </div>
 
<div id='longTitle' class='Title'> Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation  </div>

Latest revision as of 23:29, 11 December 2016

Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/157


AOP Title

Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation
Short name: DIO1i posterior swim bladder

Authors

Dries Knapen [1], [dries.knapen (at)uantwerpen.be]

Lucia Vergauwen [1], [lucia.vergauwen(at)uantwerpen.be]

Evelyn Stinckens [1], [evelyn.stinckens(at)uantwerpen.be]

Dan Villeneuve [2], [villeneuve.dan*(at)epa.gov]

[1] Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
[2]United States Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA.

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

Under development: Do not distribute or cite.

This AOP page was last modified on 12/11/2016.

Click here to show/hide revision dates for related pages

Page Revision Date/Time

OECD EAGMST AOP Development Programme Project 1.35: The adverse outcome pathway on thyroperoxidase and/or deiodinase inhibition leading to impaired swim bladder inflation in fish during early life stages.

Abstract

The AOP describes the effects of inhibition of deiodinase 1 (DIO1) on posterior swim bladder inflation leading to reduced young of year survival and population trajectory decline. The inhibition of DIO1 is the molecular-initiating event (MIE), which results in decreased circulating concentrations of triiodothyronine (T3) in serum. Disruption of the thyroid hormone (TH) system is increasingly being recognized as an important MoA that can lead to adverse outcomes, especially during embryonic development. In fish, many different adverse effects during early development resulting from disruption of the TH endocrine system have been reported (e.g., effects on body and eye size, head-to-trunk angle, heartbeat, otolith formation, pigmentation index, swim bladder inflation, hatching time, somite formation, escape response and photoreceptor development). As in amphibians, the transition in fish between the different developmental phases, including maturation and inflation of the swim bladder, have been shown to be mediated by THs. Fish larvae exposed to PTU, a known DIO1 inhibitor, has been known to result in impairment of the posterior chamber inflation. Chemicals interfering with the conversion of T4 to T3 have the potential to inhibit posterior chamber inflation which may result in reduced swimming capacity of the fish, a relevant adverse outcome that can affect feeding behaviour and predator avoidance, resulting in lower survival probability and ultimately population trajectory decline (Czesny et al., 2005; Woolley and Qin, 2010).

Summary of the AOP

Please follow link to widget page to edit this section.

If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.

Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Deiodinase 1, Inhibition

Key Events

Event Support for Essentiality
Triiodothyronine (T3) in serum, Decreased
Posterior swim bladder inflation, Reduced
Swimming performance, Reduced
Young of year survival, Reduced
Anterior swim bladder inflation, Reduced
Hearing, Reduced

Adverse Outcome

Adverse Outcome
Population trajectory, Decrease

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Deiodinase 1, Inhibition Directly Leads to Triiodothyronine (T3) in serum, Decreased
Triiodothyronine (T3) in serum, Decreased Directly Leads to Posterior swim bladder inflation, Reduced
Posterior swim bladder inflation, Reduced Directly Leads to Swimming performance, Reduced
Swimming performance, Reduced Directly Leads to Young of year survival, Reduced
Young of year survival, Reduced Directly Leads to Population trajectory, Decrease
Posterior swim bladder inflation, Reduced Directly Leads to Anterior swim bladder inflation, Reduced
Anterior swim bladder inflation, Reduced Directly Leads to Hearing, Reduced
Hearing, Reduced Directly Leads to Young of year survival, Reduced
Anterior swim bladder inflation, Reduced Directly Leads to Swimming performance, Reduced
Deiodinase 1, Inhibition Indirectly Leads to Posterior swim bladder inflation, Reduced
Posterior swim bladder inflation, Reduced Indirectly Leads to Young of year survival, Reduced Strong Weak

Network View

   Cytoscape Web will replace the contents of this div with your graph.

Click nodes or edges.

Life Stage Applicability

Life Stage Evidence Links
development

Taxonomic Applicability

Name Scientific Name Evidence Links
zebrafish Danio rerio NCBI
fathead minnow Pimephales promelas NCBI

Sex Applicability

Sex Evidence Links
Unspecific

Graphical Representation

Dio1-post.jpg

Overall Assessment of the AOP

Domain of Applicability

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.

Weight of Evidence Summary

Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.

Quantitative Considerations

Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.

Considerations for Potential Applications of the AOP (optional)

References