Difference between revisions of "Aop:157"
(→Status) |
|||
Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
− | + | = Status = | |
− | {{ | + | <span style="color:#FF0000"> |
+ | This is a legacy representation of this AOP. Please see the current version here: | ||
+ | |||
+ | [//{{SERVERNAME}}/aops/157 https://{{SERVERNAME}}/aops/157] | ||
+ | </span> | ||
+ | |||
+ | |||
== AOP Title == | == AOP Title == | ||
<div id='longTitle' class='Title'> Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation </div> | <div id='longTitle' class='Title'> Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation </div> |
Latest revision as of 23:29, 11 December 2016
Status
This is a legacy representation of this AOP. Please see the current version here:
AOP Title
Authors
Dries Knapen [1], [dries.knapen (at)uantwerpen.be]
Lucia Vergauwen [1], [lucia.vergauwen(at)uantwerpen.be]
Evelyn Stinckens [1], [evelyn.stinckens(at)uantwerpen.be]
Dan Villeneuve [2], [villeneuve.dan*(at)epa.gov]
- [1] Zebrafishlab, Veterinary Physiology and Biochemistry, Department of Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
- [2]United States Environmental Protection Agency, Mid-Continent Ecology Division, 6201 Congdon Blvd, Duluth, MN, USA.
Status
Please follow the link to snapshots page to view and create Snapshots of this AOP.
Under development: Do not distribute or cite.
This AOP page was last modified on 12/11/2016.
Click here to show/hide revision dates for related pages
Page | Revision Date/Time |
---|
OECD EAGMST AOP Development Programme Project 1.35: The adverse outcome pathway on thyroperoxidase and/or deiodinase inhibition leading to impaired swim bladder inflation in fish during early life stages.
Abstract
The AOP describes the effects of inhibition of deiodinase 1 (DIO1) on posterior swim bladder inflation leading to reduced young of year survival and population trajectory decline. The inhibition of DIO1 is the molecular-initiating event (MIE), which results in decreased circulating concentrations of triiodothyronine (T3) in serum. Disruption of the thyroid hormone (TH) system is increasingly being recognized as an important MoA that can lead to adverse outcomes, especially during embryonic development. In fish, many different adverse effects during early development resulting from disruption of the TH endocrine system have been reported (e.g., effects on body and eye size, head-to-trunk angle, heartbeat, otolith formation, pigmentation index, swim bladder inflation, hatching time, somite formation, escape response and photoreceptor development). As in amphibians, the transition in fish between the different developmental phases, including maturation and inflation of the swim bladder, have been shown to be mediated by THs. Fish larvae exposed to PTU, a known DIO1 inhibitor, has been known to result in impairment of the posterior chamber inflation. Chemicals interfering with the conversion of T4 to T3 have the potential to inhibit posterior chamber inflation which may result in reduced swimming capacity of the fish, a relevant adverse outcome that can affect feeding behaviour and predator avoidance, resulting in lower survival probability and ultimately population trajectory decline (Czesny et al., 2005; Woolley and Qin, 2010).
Summary of the AOP
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
---|---|
Deiodinase 1, Inhibition |
Key Events
Adverse Outcome
Adverse Outcome |
---|
Population trajectory, Decrease |
Relationships Among Key Events and the Adverse Outcome
Network View
Cytoscape Web will replace the contents of this div with your graph.
Click nodes or edges.
Life Stage Applicability
Life Stage | Evidence | Links |
---|---|---|
development |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|---|---|---|
zebrafish | Danio rerio | NCBI | |
fathead minnow | Pimephales promelas | NCBI |
Sex Applicability
Sex | Evidence | Links |
---|---|---|
Unspecific |
Graphical Representation
Overall Assessment of the AOP
Domain of Applicability
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Weight of Evidence Summary
Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.