Difference between revisions of "Aop:195"
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== AOP Title == | == AOP Title == | ||
<div id='longTitle' class='Title'> 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase </div> | <div id='longTitle' class='Title'> 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase </div> |
Latest revision as of 23:56, 11 December 2016
Status
This is a legacy representation of this AOP. Please see the current version here:
AOP Title
Authors
Kellie Fay
Status
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This AOP page was last modified on 12/11/2016.
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Page | Revision Date/Time |
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Abstract
Increased serotonergic activity resulting from the inhibition of the 5-hydroxytryptamin transporter (5-HTT; SERT; serotonin reuptake transporter) may result in increased population levels of certain mollusks, specifically invasive mussels. Gamete maturation and release are under serotonergic control and several mussel species have been reported to release viable gametes (both sperm and oocytes)upon exposure to serotonin or 5-HTT inhibitors, which increase serotonergic signalling. Given the critically low population levels of many Unionid species and the difficulty in managing several invasive (Dreissenid; e.g., zebra mussel) species, increased reproductive success may result in adverse outcomes at an ecosystem level.
Background (optional)
Summary of the AOP
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Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
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5-hydroxytryptamine transporter (5-HTT; SERT), Inhibition | Strong |
Key Events
Event | Support for Essentiality |
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serotonin (5-HT) , Increased | |
mantel display, Increased | |
gamete maturation, Increased | |
cilia movement, Increased | |
Spawning , premature | |
Reproductive Success, Increased |
Adverse Outcome
Adverse Outcome |
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Population, Increased |
Relationships Among Key Events and the Adverse Outcome
Network View
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Life Stage Applicability
Life Stage | Evidence | Links |
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Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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Argopecten irradians | Argopecten irradians | Weak | NCBI |
Mercenaria mercenaria | Mercenaria mercenaria | Weak | NCBI |
Arctica islandica | Arctica islandica | Weak | NCBI |
Spisula solidissima | Spisula solidissima | Weak | NCBI |
Anodonta cygnea | Anodonta cygnea | Weak | NCBI |
Dreissena polymorpha | Dreissena polymorpha | Weak | NCBI |
Sex Applicability
Sex | Evidence | Links |
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Graphical Representation
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Overall Assessment of the AOP
This aop should be considered highly putative. SSRI effects in mussels have been fairly well documented as a method to increase reproduction in aquaculture settings, but the implications on natural population and potential ecosystem effects are unknown.
Domain of Applicability
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Weight of Evidence Summary
Summary Table
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Quantitative Considerations
Summary Table
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