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== Summary of the AOP == | == Summary of the AOP == | ||
[[Category:Adverse Outcome Pathway]] | [[Category:Adverse Outcome Pathway]] | ||
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=== Molecular Initiating Event === | === Molecular Initiating Event === | ||
Revision as of 01:40, 29 September 2014
AOP Title
Authors
Status
Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.
Under development: Do not distribute or cite.
Putative AOP - under development for International Workshop on Advancing AOPs for Integrated Toxicology and Regulatory Applications
Abstract
Summary of the AOP
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Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
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Cyclooxygenase activity, Inhibition |
Key Events
Event | Support for Essentiality |
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Prostaglandin E2 concentration, Reduction | |
Ca and HCO3 transport to shell gland, Reduction | |
Eggshell thickness, Reduction | |
Reproductive failure, N/A | |
Gap, N/A |
Adverse Outcome
Adverse Outcome |
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Reproduction, Failure |
Relationships Among Key Events and the Adverse Outcome
Network View
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Click nodes or edges.
Life Stage Applicability
Life Stage | Evidence | Links |
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Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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Sex Applicability
Sex | Evidence | Links |
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Graphical Representation
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Overall Assessment of the AOP
Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.
Weight of Evidence Summary
Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.
Applicability of the AOP
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.