Difference between revisions of "Aop:28"
Line 80: | Line 80: | ||
!Molecular Initiating Event | !Molecular Initiating Event | ||
!Evidence | !Evidence | ||
+ | |||
+ | |- | ||
+ | |||
+ | |[[Cyclooxygenase activity, Inhibition]]||||<html><button id="edit" name="Molecular Initiating Event"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Molecular Initiating Event"><span class="ui-icon ui-icon-trash"></span></button></html> | ||
|- | |- |
Revision as of 14:50, 5 February 2014
<html> <style> .ui-autocomplete {
max-height: 100px; overflow-y: auto; overflow-x: hidden; padding-right: 20px;
}
- html .ui-autocomplete {
height: 100px;
}
.ui-menu .ui-menu-item a
{ display: block; padding: 1px 1px 1px 1px; text-decoration: none; cursor: pointer; font-size: 13px; }
</style>
<link type='text/css' rel='stylesheet' href='/extensions/jquery-ui-1.9.2/themes/base/jquery-ui.css'> <script type="text/javascript" src="/extensions/jquery-ui-1.9.2/ui/jquery-ui.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Key_Event.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Chemicals.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Species.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Endpoint.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Life_Stage.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Sex.js"></script>
</html>
Status
Under development: Do not distribute or cite.
Introduction
Summary of the AOP
Molecular Initiating Event
<html> <button id="TableAdd3">Add Molecular Initiating Event to Table</button> </html>
Molecular Initiating Event | Evidence | |
---|---|---|
Cyclooxygenase activity, Inhibition | <html><button id="edit" name="Molecular Initiating Event"></button><button id="del" name="Molecular Initiating Event"></button></html> |
Key Events
<html> <button id="TableAdd4">Add Event to Table</button> </html>
Event | Evidence |
---|
Adverse Outcome
<html> <button id="TableAdd5">Add Adverse Outcome to Table</button> </html>
Adverse Outcome | Evidence |
---|
Relationships Among Key Events and the Adverse Outcome
<html> <button id="TableAdd">Add record to table</button> </html>
Step | Event | Description | Triggers | Weight of Evidence |
---|
Life Stage Applicability
<html> <button id="LifeStageList">Add Life Stage to table</button> </html>
Life Stage | Evidence | Links |
---|
Taxonomic Applicability
<html> <button id="SpeciesList" >Add Species from list</button> </html>
Name | Scientific Name | Evidence | Links |
---|
Sex Applicability
<html> <button id="SexList" >Add a Sex to table</button> </html>
Sex | Evidence | Links |
---|
Graphical Representation
Click to upload graphical representation
Assessment of the AOP
Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.
Confidence in the AOP
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.