Difference between revisions of "Aop:28"
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− | |1||[[Cyclooxygenase activity, Inhibition]]||Leads to||[[Prostaglandin E2 concentration, Reduction]]||[[Cyclooxygenase activity, Inhibition Leads to Prostaglandin E2 concentration, Reduction|Moderate]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> | + | |1||[[Cyclooxygenase activity, Inhibition]]||[[Cyclooxygenase activity, Inhibition Relating to Prostaglandin E2 concentration, Reduction|Directly Leads to]]||[[Prostaglandin E2 concentration, Reduction]]||[[Cyclooxygenase activity, Inhibition Leads to Prostaglandin E2 concentration, Reduction|Moderate]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> |
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− | |2||[[Prostaglandin E2 concentration, Reduction]]||Leads to||[[Gap, N/A]]||[[Prostaglandin E2 concentration, Reduction Leads to Gap, N/A|Not Specified]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> | + | |2||[[Prostaglandin E2 concentration, Reduction]]||[[Prostaglandin E2 concentration, Reduction Relating to Gap, N/A|Directly Leads to]]||[[Gap, N/A]]||[[Prostaglandin E2 concentration, Reduction Leads to Gap, N/A|Not Specified]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> |
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− | |3||[[Gap, N/A]]||Leads to||[[Ca and HCO3 transport to shell gland, Reduction]]||[[Gap, N/A Leads to Ca and HCO3 transport to shell gland, Reduction|Not Specified]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> | + | |3||[[Gap, N/A]]||[[Gap, N/A Relating to Ca and HCO3 transport to shell gland, Reduction|Directly Leads to]]||[[Ca and HCO3 transport to shell gland, Reduction]]||[[Gap, N/A Leads to Ca and HCO3 transport to shell gland, Reduction|Not Specified]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> |
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− | |4||[[Ca and HCO3 transport to shell gland, Reduction]]||Leads to||[[Eggshell thickness, Reduction]]||[[Ca and HCO3 transport to shell gland, Reduction Leads to Eggshell thickness, Reduction|Moderate]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> | + | |4||[[Ca and HCO3 transport to shell gland, Reduction]]||[[Ca and HCO3 transport to shell gland, Reduction Relating to Eggshell thickness, Reduction|Directly Leads to]]||[[Eggshell thickness, Reduction]]||[[Ca and HCO3 transport to shell gland, Reduction Leads to Eggshell thickness, Reduction|Moderate]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> |
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− | |5||[[Eggshell thickness, Reduction]]||Leads to||[[Reproductive failure, N/A]]||[[Eggshell thickness, Reduction Leads to Reproductive failure, N/A|Strong]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> | + | |5||[[Eggshell thickness, Reduction]]||[[Eggshell thickness, Reduction Relating to Reproductive failure, N/A|Directly Leads to]]||[[Reproductive failure, N/A]]||[[Eggshell thickness, Reduction Leads to Reproductive failure, N/A|Strong]]||||<html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-pencil"></span></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"><span class="ui-icon ui-icon-trash"></span></button></html> |
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Revision as of 22:30, 8 April 2014
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Authors
Status
Under development: Do not distribute or cite.
Putative AOP - under development for International Workshop on Advancing AOPs for Integrated Toxicology and Regulatory Applications
Abstract
Summary of the AOP
Molecular Initiating Event
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Molecular Initiating Event | Support for Essentiality | |
---|---|---|
Cyclooxygenase activity, Inhibition | <html><button id="edit" name="Molecular Initiating Event"></button><button id="del" name="Molecular Initiating Event"></button></html> |
Key Events
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Event | Support for Essentiality | |
---|---|---|
Prostaglandin E2 concentration, Reduction | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Ca and HCO3 transport to shell gland, Reduction | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Eggshell thickness, Reduction | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Reproductive failure, N/A | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Gap, N/A | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> |
Adverse Outcome
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Adverse Outcome | |
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Reproduction, failure | <html><button id="edit" name="Adverse Outcome"></button><button id="del" name="Adverse Outcome"></button></html> |
Relationships Among Key Events and the Adverse Outcome
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Step | Event | Description | Triggers | Weight of Evidence | Quantitative Understanding | |
---|---|---|---|---|---|---|
1 | Cyclooxygenase activity, Inhibition | Directly Leads to | Prostaglandin E2 concentration, Reduction | Moderate | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> | |
2 | Prostaglandin E2 concentration, Reduction | Directly Leads to | Gap, N/A | Not Specified | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> | |
3 | Gap, N/A | Directly Leads to | Ca and HCO3 transport to shell gland, Reduction | Not Specified | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> | |
4 | Ca and HCO3 transport to shell gland, Reduction | Directly Leads to | Eggshell thickness, Reduction | Moderate | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> | |
5 | Eggshell thickness, Reduction | Directly Leads to | Reproductive failure, N/A | Strong | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> |
Network View
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Life Stage Applicability
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Life Stage | Evidence | Links |
---|
Taxonomic Applicability
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Name | Scientific Name | Evidence | Links |
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Sex Applicability
<html> <button id="SexList" >Add a Sex to table</button> </html>
Sex | Evidence | Links |
---|
Graphical Representation
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Confidence in the AOP
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Overall Assessment of the AOP
Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.
Weight of Evidence Summary
Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.
Applicability of the AOP
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.