Difference between revisions of "Aop:28"
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+ | This is a legacy representation of this AOP. Please see the current version here: | ||
− | {{ | + | [//{{SERVERNAME}}/aops/28 https://{{SERVERNAME}}/aops/28] |
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<div class='Title'> Cyclooxygenase inhibition leading reproductive failure </div> | <div class='Title'> Cyclooxygenase inhibition leading reproductive failure </div> | ||
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<div id='shortTitle' class='Title2'>Short name: Cyclooxygenase inhibition leading reproductive failure </div> | <div id='shortTitle' class='Title2'>Short name: Cyclooxygenase inhibition leading reproductive failure </div> | ||
== Authors == | == Authors == | ||
+ | Dan Villeneuve, US EPA Mid-Continent Ecology Division (villeneuve.dan@epa.gov) | ||
== Status == | == Status == | ||
+ | |||
+ | '''Please follow the link to [//{{SERVERNAME}}/aops/{{PAGENAMEE}}/snapshots snapshots page] to view and create Snapshots of this AOP.''' | ||
+ | |||
'''Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.''' | '''Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.''' | ||
'''Under development: Do not distribute or cite.''' | '''Under development: Do not distribute or cite.''' | ||
− | Putative AOP | + | Putative AOP |
+ | |||
+ | '''Project 1.29''': A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification | ||
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+ | This AOP page was last modified on {{REVISIONMONTH1}}/{{REVISIONDAY}}/{{REVISIONYEAR}}. | ||
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+ | <span id='ToggleRevision' style="text-decoration: underline;">Click here to show/hide revision dates for related pages</span> | ||
+ | {|class="wikitable sortable" id="Revtable" | ||
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+ | !Page | ||
+ | !Revision Date/Time | ||
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+ | |} | ||
== Abstract == | == Abstract == | ||
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== Summary of the AOP == | == Summary of the AOP == | ||
[[Category:Adverse Outcome Pathway]] | [[Category:Adverse Outcome Pathway]] | ||
+ | Please follow link to [//{{SERVERNAME}}/aops/{{PAGENAMEE}} widget page] to edit this section. | ||
+ | |||
+ | <span style="color:#FF0000">'''If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.'''</span> | ||
=== Molecular Initiating Event === | === Molecular Initiating Event === | ||
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{|class="wikitable sortable" id="MIEproof" | {|class="wikitable sortable" id="MIEproof" | ||
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− | |[[Cyclooxygenase activity, Inhibition]] | + | |[[Event:79|Cyclooxygenase activity, Inhibition]]|| |
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=== Key Events === | === Key Events === | ||
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{|class="wikitable sortable" id="KEproof" | {|class="wikitable sortable" id="KEproof" | ||
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− | |[[Prostaglandin E2 concentration, Reduction]] | + | |[[Event:243|Prostaglandin E2 concentration, Reduction]]|| |
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− | |[[Ca and HCO3 transport to shell gland, Reduction]] | + | |[[Event:49|Ca and HCO3 transport to shell gland, Reduction]]|| |
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− | |[[Eggshell thickness, Reduction]] | + | |[[Event:106|Eggshell thickness, Reduction]]|| |
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− | |[[ | + | |[[Event:119|Gap, N/A]]|| |
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=== Adverse Outcome === | === Adverse Outcome === | ||
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{|class="wikitable sortable" id="AOproof" | {|class="wikitable sortable" id="AOproof" | ||
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− | |[[ | + | |[[Event:253|Reproductive failure, N/A]] |
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=== Relationships Among Key Events and the Adverse Outcome === | === Relationships Among Key Events and the Adverse Outcome === | ||
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{| class="wikitable sortable" id="relation" | {| class="wikitable sortable" id="relation" | ||
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!Event | !Event | ||
!Description | !Description | ||
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− | + | |[[Event:79|Cyclooxygenase activity, Inhibition]]||[[Relationship:95|Directly Leads to]]||[[Event:243|Prostaglandin E2 concentration, Reduction]]||[[Relationship:95#Weight of Evidence|Moderate]]|| | |
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− | + | |[[Event:243|Prostaglandin E2 concentration, Reduction]]||[[Relationship:268|Directly Leads to]]||[[Event:119|Gap, N/A]]||[[Relationship:268#Weight of Evidence|Not Specified]]|| | |
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− | + | |[[Event:119|Gap, N/A]]||[[Relationship:136|Directly Leads to]]||[[Event:49|Ca and HCO3 transport to shell gland, Reduction]]||[[Relationship:136#Weight of Evidence|Not Specified]]|| | |
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− | + | |[[Event:49|Ca and HCO3 transport to shell gland, Reduction]]||[[Relationship:59|Directly Leads to]]||[[Event:106|Eggshell thickness, Reduction]]||[[Relationship:59#Weight of Evidence|Moderate]]|| | |
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− | + | |[[Event:106|Eggshell thickness, Reduction]]||[[Relationship:123|Directly Leads to]]||[[Event:253|Reproductive failure, N/A]]||[[Relationship:123#Weight of Evidence|Strong]]|| | |
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=== Life Stage Applicability === | === Life Stage Applicability === | ||
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{|class="wikitable sortable" id="LSproof" | {|class="wikitable sortable" id="LSproof" | ||
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=== Taxonomic Applicability === | === Taxonomic Applicability === | ||
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{|class="wikitable sortable" id="Specproof" | {|class="wikitable sortable" id="Specproof" | ||
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=== Sex Applicability === | === Sex Applicability === | ||
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{|class="wikitable sortable" id="Sexproof" | {|class="wikitable sortable" id="Sexproof" | ||
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=== Graphical Representation === | === Graphical Representation === | ||
− | *[ | + | *[https://aopkb.org/common/AOP_Graphic_Template2.pptx Click to download template for graphical representation] |
[[File:Cyclooxygenase inhibition leading reproductive failure.jpg | 900px | Click to upload graphical representation]] | [[File:Cyclooxygenase inhibition leading reproductive failure.jpg | 900px | Click to upload graphical representation]] |
Latest revision as of 18:39, 11 December 2016
Status
This is a legacy representation of this AOP. Please see the current version here:
AOP Title
Authors
Dan Villeneuve, US EPA Mid-Continent Ecology Division (villeneuve.dan@epa.gov)
Status
Please follow the link to snapshots page to view and create Snapshots of this AOP.
Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.
Under development: Do not distribute or cite.
Putative AOP
Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification
This AOP page was last modified on 12/11/2016.
Click here to show/hide revision dates for related pages
Page | Revision Date/Time |
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Abstract
Summary of the AOP
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
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Cyclooxygenase activity, Inhibition |
Key Events
Event | Support for Essentiality |
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Prostaglandin E2 concentration, Reduction | |
Ca and HCO3 transport to shell gland, Reduction | |
Eggshell thickness, Reduction | |
Gap, N/A |
Adverse Outcome
Adverse Outcome |
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Reproductive failure, N/A |
Relationships Among Key Events and the Adverse Outcome
Network View
Cytoscape Web will replace the contents of this div with your graph.
Click nodes or edges.
Life Stage Applicability
Life Stage | Evidence | Links |
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Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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Sex Applicability
Sex | Evidence | Links |
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Graphical Representation
Click to upload graphical representation
Overall Assessment of the AOP
Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.
Weight of Evidence Summary
Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.
Applicability of the AOP
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.