Difference between revisions of "Aop:28"

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= Status =
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This is a legacy representation of this AOP. Please see the current version here:
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[//{{SERVERNAME}}/aops/28 https://{{SERVERNAME}}/aops/28]
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== AOP Title ==
 
== AOP Title ==
  
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== Authors ==
 
== Authors ==
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Dan Villeneuve, US EPA Mid-Continent Ecology Division (villeneuve.dan@epa.gov)
  
 
== Status ==
 
== Status ==
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'''Please follow the link to [//{{SERVERNAME}}/aops/{{PAGENAMEE}}/snapshots snapshots page] to view and create Snapshots of this AOP.'''
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'''Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.'''
 
'''Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.'''
  
 
'''Under development:  Do not distribute or cite.'''
 
'''Under development:  Do not distribute or cite.'''
  
Putative AOP - under development for International Workshop on Advancing AOPs for Integrated Toxicology and Regulatory Applications
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Putative AOP
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'''Project 1.29''': A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification
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This AOP page was last modified on {{REVISIONMONTH1}}/{{REVISIONDAY}}/{{REVISIONYEAR}}.
 
This AOP page was last modified on {{REVISIONMONTH1}}/{{REVISIONDAY}}/{{REVISIONYEAR}}.
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== Summary of the AOP ==
 
== Summary of the AOP ==
 
[[Category:Adverse Outcome Pathway]]
 
[[Category:Adverse Outcome Pathway]]
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Please follow link to [//{{SERVERNAME}}/aops/{{PAGENAMEE}} widget page] to edit this section.
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=== Molecular Initiating Event ===
 
=== Molecular Initiating Event ===
  
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|[[Event:106|Eggshell thickness, Reduction]]||
 
|[[Event:106|Eggshell thickness, Reduction]]||
 
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|[[Event:253|Reproductive failure, N/A]]||
 
  
 
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|[[Event:362|Reproduction, Failure]]
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=== Life Stage Applicability ===
 
=== Life Stage Applicability ===
  

Latest revision as of 18:39, 11 December 2016

Status

This is a legacy representation of this AOP. Please see the current version here:

https://aopwiki.org/aops/28


AOP Title

Cyclooxygenase inhibition leading reproductive failure
Short name: Cyclooxygenase inhibition leading reproductive failure

Authors

Dan Villeneuve, US EPA Mid-Continent Ecology Division (villeneuve.dan@epa.gov)

Status

Please follow the link to snapshots page to view and create Snapshots of this AOP.

Alert: The Weight of Evidence column in the Molecular Initiating Event and Key Event tables has changed to Essentiality. Consider re-evaluating the columns in these tables.

Under development: Do not distribute or cite.

Putative AOP

Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification


This AOP page was last modified on 12/11/2016.

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Page Revision Date/Time

Abstract

Summary of the AOP

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Molecular Initiating Event

Molecular Initiating Event Support for Essentiality
Cyclooxygenase activity, Inhibition

Key Events

Event Support for Essentiality
Prostaglandin E2 concentration, Reduction
Ca and HCO3 transport to shell gland, Reduction
Eggshell thickness, Reduction
Gap, N/A

Adverse Outcome

Adverse Outcome
Reproductive failure, N/A

Relationships Among Key Events and the Adverse Outcome

Event Description Triggers Weight of Evidence Quantitative Understanding
Cyclooxygenase activity, Inhibition Directly Leads to Prostaglandin E2 concentration, Reduction Moderate
Prostaglandin E2 concentration, Reduction Directly Leads to Gap, N/A Not Specified
Gap, N/A Directly Leads to Ca and HCO3 transport to shell gland, Reduction Not Specified
Ca and HCO3 transport to shell gland, Reduction Directly Leads to Eggshell thickness, Reduction Moderate
Eggshell thickness, Reduction Directly Leads to Reproductive failure, N/A Strong

Network View

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Life Stage Applicability

Life Stage Evidence Links

Taxonomic Applicability

Name Scientific Name Evidence Links

Sex Applicability

Sex Evidence Links

Graphical Representation

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Overall Assessment of the AOP

Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.

Weight of Evidence Summary

Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.

Essentiality of the Key Events

Molecular Initiating Event Summary, Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.

Quantitative Considerations

Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.

Applicability of the AOP

Life Stage Applicability, Taxonomic Applicability, Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

Considerations for Potential Applications of the AOP (optional)

References