Aop:28
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Status
Under development: Do not distribute or cite.
Introduction
Summary of the AOP
Molecular Initiating Event
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Molecular Initiating Event | Evidence | |
---|---|---|
Cyclooxygenase activity, Inhibition | <html><button id="edit" name="Molecular Initiating Event"></button><button id="del" name="Molecular Initiating Event"></button></html> |
Key Events
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Event | Evidence | |
---|---|---|
Prostaglandin E2 concentration, Reduction | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Ca and HCO3 transport to shell gland, Reduction | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Eggshell thickness, Reduction | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Reproductive failure, N/A | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> | |
Gap, N/A | <html><button id="edit" name="Key Events"></button><button id="del" name="Key Events"></button></html> |
Adverse Outcome
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Adverse Outcome | Evidence |
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Relationships Among Key Events and the Adverse Outcome
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Step | Event | Description | Triggers | Weight of Evidence | |
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1 | Cyclooxygenase activity, Inhibition | Leads to | Prostaglandin E2 concentration, Reduction | Moderate | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> |
2 | Prostaglandin E2 concentration, Reduction | Leads to | Gap, N/A | Not Specified | <html><button id="edit" name="Relationships Among Key Events and the Adverse Outcome"></button><button id="del" name="Relationships Among Key Events and the Adverse Outcome"></button></html> |
Life Stage Applicability
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Life Stage | Evidence | Links |
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Taxonomic Applicability
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Name | Scientific Name | Evidence | Links |
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Sex Applicability
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Sex | Evidence | Links |
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Graphical Representation
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Assessment of the AOP
Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.
Confidence in the AOP
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.