Aop:39

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Status

Under development: Do not distribute or cite.

Introduction

Summary of the AOP

Molecular Initiating Event

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Molecular Initiating Event Evidence
Covalent binding to proteins, N/A Strong <html><button id="edit" name="Molecular Initiating Event"></button><button id="del" name="Molecular Initiating Event"></button></html>

Key Events

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Event Evidence

Adverse Outcome

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Adverse Outcome Evidence

Relationships Among Key Events and the Adverse Outcome

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Step Event Description Triggers Weight of Evidence

Life Stage Applicability

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Life Stage Evidence Links

Taxonomic Applicability

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Name Scientific Name Evidence Links

Sex Applicability

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Sex Evidence Links

Graphical Representation

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Assessment of the AOP

Consider the following criteria (may include references to KE Relationship pages): 1. concordance of dose-response relationships; 2. temporal concordance among the key events and adverse effect; 3. strength, consistency, and specificity of association of adverse effect and initiating event; 4. biological plausibility, coherence, and consistency of the experimental evidence; 5. alternative mechanisms that logically present themselves and the extent to which they may distract from the postulated AOP. It should be noted that alternative mechanisms of action, if supported, require a separate AOP; 6. uncertainties, inconsistencies and data gaps.

Confidence in the AOP

Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.

References