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Status
Under development: Do not distribute or cite.
Introduction
Summary of the AOP
Molecular Initiating Event
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<button id="TableAdd3">Add Molecular Initiating Event to Table</button>
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Action
</br>
<input type=text id="describeMIE" style="float:left"></input>
</br>
</br>
Biological Process/Object
</br>
</html>
Unknown extension tag "createbox"
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</br>
</br>
Evidence
</br>
<select id="weightMIE">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
<button id="SubMIE">Submit</button>
<button id="EditMIE">Submit</button>
</html>
Molecular Initiating Event
|
Evidence
|
Covalent binding to proteins, N/A |
Strong |
<html><button id="edit" name="Molecular Initiating Event"></button><button id="del" name="Molecular Initiating Event"></button></html>
|
Key Events
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<button id="TableAdd4">Add Event to Table</button>
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Action
</br>
<input type=text id="describeKE" style="float:left"></input>
</br>
</br>
Biological Process/Object
</br>
</html>
Unknown extension tag "createbox"
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</br>
</br>
Evidence
</br>
<select id="weightKE">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
<button id="SubKE">Submit</button>
<button id="EditKE">Submit</button>
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Adverse Outcome
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<button id="TableAdd5">Add Adverse Outcome to Table</button>
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Action
</br>
<input type=text id="describeAO" style="float:left"></input>
</br>
</br>
Biological Process/Object
</br>
</html>
Unknown extension tag "createbox"
<html>
</br>
</br>
Evidence
</br>
<select id="weightAO">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
<button id="SubAO">Submit</button>
<button id="EditAO">Submit</button>
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Relationships Among Key Events and the Adverse Outcome
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<button id="TableAdd">Add record to table</button>
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Step
</br>
<input type=text id="step"></input>
</br>
</br>
Event
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<select id="upstream"></select>
</br>
</br>
Description
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<select id="describe">
<option></option>
<option>Leads to</option>
<option>Blocks</option>
</select>
</br>
</br>
Triggers
</br>
<select id="downstream"></select>
</br>
</br>
Weight of Evidence
</br>
<select id="weight">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
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Unknown extension tag "createbox"
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<button id="SubRel">Submit</button>
<button id="EditRel">Submit</button>
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Step
|
Event
|
Description
|
Triggers
|
Weight of Evidence
|
Life Stage Applicability
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<button id="LifeStageList">Add Life Stage to table</button>
</html>
<html>
Biological Process/Object
</br>
</html>
Unknown extension tag "createbox"
<html>
</br>
</br>
Evidence
</br>
<select id="weightLife">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
<button id="SubLife">Submit</button>
<button id="EditLife">Submit</button>
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Life Stage
|
Evidence
|
Links
|
Taxonomic Applicability
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<button id="SpeciesList" >Add Species from list</button>
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Biological Object
</br>
</html>
Unknown extension tag "createbox"
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</br>
</br>
Scientific Name
</br>
<select id="scientificSpecies"><select>
</br>
</br>
Evidence
</br>
<select id="weightSpec">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
<button id="SubSpec">Submit</button>
<button id="EditSpec">Submit</button>
<button id="SubNext">Next</button>
<button id="EditNext">Next</button>
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Name
|
Scientific Name
|
Evidence
|
Links
|
Sex Applicability
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<button id="SexList" >Add a Sex to table</button>
</html>
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Biological Process/Object
</br>
<input type=text id="sexInput" style="float:left"></input>
</br>
</br>
Evidence
</br>
<select id="weightSex">
<option></option>
<option>Very Strong</option>
<option>Strong</option>
<option>Moderate</option>
<option>Weak</option>
<option>Very Weak</option>
</select>
</br>
</br>
<button id="SubSex">Submit</button>
<button id="EditSex">Submit</button>
</html>
Graphical Representation
Click to upload graphical representation
Assessment of the AOP
Consider the following criteria (may include references to KE Relationship pages):
1. concordance of dose-response relationships;
2. temporal concordance among the key events and adverse effect;
3. strength, consistency, and specificity of association of adverse effect and initiating event;
4. biological plausibility, coherence, and consistency of the experimental evidence;
5. alternative mechanisms that logically present themselves and the extent to which they may
distract from the postulated AOP. It should be noted that alternative mechanisms of action, if
supported, require a separate AOP;
6. uncertainties, inconsistencies and data gaps.
Confidence in the AOP
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
References