Aop:57
Status
This is a legacy representation of this AOP. Please see the current version here:
AOP Title
Authors
Michelle Angrish
Status
Please follow the link to snapshots page to view and create Snapshots of this AOP.
Under development: Do not distribute or cite.
This AOP page was last modified on 12/11/2016.
Click here to show/hide revision dates for related pages
Page | Revision Date/Time |
---|
Abstract
Background (optional)
Summary of the AOP
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
---|---|
AHR, Activation | Strong |
Key Events
Adverse Outcome
Adverse Outcome |
---|
Liver lipid, Accumulation |
Relationships Among Key Events and the Adverse Outcome
Network View
Cytoscape Web will replace the contents of this div with your graph.
Click nodes or edges.
Life Stage Applicability
Life Stage | Evidence | Links |
---|
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|---|---|---|
mouse | Mus musculus | Strong | NCBI |
Sex Applicability
Sex | Evidence | Links |
---|
Graphical Representation
Click to upload graphical representation
Overall Assessment of the AOP
Domain of Applicability
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Weight of Evidence Summary
Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.