Difference between revisions of "Aop:58"
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|[[Event:54|CD36, Up Regulation]]||[[Relationship:494|Directly Leads to]]||[[Event:460|Fatty acid uptake, Increased]]||[[Relationship:494#Weight of Evidence|Strong]]||[[Relationship:494#Quantitative Understanding of the Linkage|Strong]] | |[[Event:54|CD36, Up Regulation]]||[[Relationship:494|Directly Leads to]]||[[Event:460|Fatty acid uptake, Increased]]||[[Relationship:494#Weight of Evidence|Strong]]||[[Relationship:494#Quantitative Understanding of the Linkage|Strong]] | ||
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+ | |[[Event:167|LXR, Activation]]||[[Relationship:510|Indirectly Leads to]]||[[Event:468|PPAR alpha, Inhibition]]|||| | ||
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Revision as of 20:17, 12 March 2015
AOP Title
Authors
Michelle Angrish, Brian Chorley
Status
Under development: Do not distribute or cite. OECD Project 1.29: A catalog of putative AOPs that will enhance the utility of US EPA Toxcast high throughput screening data for hazard identification
This AOP page was last modified on 3/12/2015.
Click here to show/hide revision dates for related pages
Page | Revision Date/Time |
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Abstract
Background (optional)
Summary of the AOP
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Molecular Initiating Event
Molecular Initiating Event | Support for Essentiality |
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Constitutive androstane receptor, NR1l3, Suppression | Moderate |
PPAR alpha, Inhibition | |
LXR, Activation | |
PPAR gamma, Activation |
Key Events
Adverse Outcome
Adverse Outcome |
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Liver Steatosis, Increased |
Relationships Among Key Events and the Adverse Outcome
Network View
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Life Stage Applicability
Life Stage | Evidence | Links |
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Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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human, mouse, rat | Moderate | NCBI |
Sex Applicability
Sex | Evidence | Links |
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Graphical Representation
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Overall Assessment of the AOP
Domain of Applicability
Life Stage Applicability,
Taxonomic Applicability,
Sex Applicability
Elaborate on the domains of applicability listed in the summary section above. Specifically, provide the literature supporting, or excluding, certain domains.
Essentiality of the Key Events
Molecular Initiating Event Summary,
Key Event Summary
Provide an overall assessment of the essentiality for the key events in the AOP. Support calls for individual key events can be included in the molecular initiating event, key event, and adverse outcome tables above.
Weight of Evidence Summary
Summary Table
Provide an overall summary of the weight of evidence based on the evaluations of the individual linkages from the Key Event Relationship pages.
Quantitative Considerations
Summary Table
Provide an overall discussion of the quantitative information available for this AOP. Support calls for the individual relationships can be included in the Key Event Relationship table above.