Event:1005

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Event Title

Swimming performance, Reduced

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Deiodinase 2 inhibition leading to reduced young of year survival via posterior swim bladder inflation KE
Deiodinase 2 inhibition leading to reduced young of year survival via anterior swim bladder inflation KE
Deiodinase 1 inhibition leading to reduced young of year survival via posterior swim bladder inflation KE
Deiodinase 1 inhibition leading to reduced young of year survival via anterior swim bladder inflation KE
Thyroperoxidase inhibition leading to reduced young of year survival via anterior swim bladder inflation KE

Taxonomic Applicability

Name Scientific Name Evidence Links
zebrafish Danio rerio NCBI

Level of Biological Organization

Biological Organization
Individual

How this Key Event works

Adequate swimming performance in fish is essential for behaviour such as foraging, predator avoidance and reproduction.

How it is Measured or Detected

For fish larvae, automated observation and tracking systems are commercially available and increasingly used for measuring swimming performance including distance travelled, duration of movements, swimming speed, etc. This kind of measurements is often included in publications describing effects of chemicals in zebrafish larvae (Hagenaars et al., 2014; Stinckens et al., 2016; Vergauwen et al., 2015).

Evidence Supporting Taxonomic Applicability

Importance of swimming performance for natural behaviour is generally applicable to fish.

References

Hagenaars, A., Stinckens, E., Vergauwen, L., Bervoets, L., Knapen, D., 2014. PFOSaffects posterior swim bladder chamber inflation and swimming performanceof zebrafish larvae. Aquat. Toxicol. 157, 225–235.

Stinckens, E., Vergauwen, L., Schroeder, A.L., Maho, W., Blackwell, B., Witter, H.,Blust, R., Ankley, G.T., Covaci, A., Villenueve, D.L., Knapen, D., 2016. Disruption of thyroid hormone balance after 2-mercaptobenzothiazole exposure causes swim bladder inflation impairment—part II: zebrafish. Aquat. Toxicol. 173:204-17.

Vergauwen, Lucia; Nørgaard Schmidt, Stine; Maho, Walid; Stickens, Evelyn; Hagenaars, An; Blust, Ronny; Mayer, Philipp; Covaci, Adrian; Knapen, Dries. 2014. A high throughput passive dosing format for the Fish Embryo Acute Toxicity test. Chemosphere. 139: 9-17.