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Event Title

Sustained Cell Proliferation, Induction
Short name: Sustained Cell Proliferation, Induction

Key Event Overview

AOPs Including This Key Event

AOP Name Molecular Initiating Event? Essentiality
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors No Strong

Taxonomic Applicability

Common Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability