Event:351

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Event Title

Mortality, Increased
Short name: Mortality, Increased

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Acetylcholinesterase inhibition leading to acute mortality AO
Axonal sodium channel modulation leading to acute mortality AO
Altered ion channel activity leading impaired heart function AO
Glutamate-gated chloride channel activation leading to acute mortality AO
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality AO [[Aop:160#Essentiality of the Key Events|]]
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality AO [[Aop:161#Essentiality of the Key Events|]]
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality AO [[Aop:138#Essentiality of the Key Events|]]
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality AO [[Aop:177#Essentiality of the Key Events|]]
unknown MIE leading to renal failure and mortality AO [[Aop:186#Essentiality of the Key Events|]]
Ecdysone receptor agonism leading to mortality AO [[Aop:4#Essentiality of the Key Events|]]

Taxonomic Applicability

Name Scientific Name Evidence Links

Affected Organs

Synonym Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Evidence Supporting Taxonomic Applicability

References