Event:541

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Event Title

Decreased COUP-TFII stem Leydig cells, Decreased testosterone by the fetal Leydig cells
Decreased COUP-TFII stem Leydig cells, Decreased testosterone by the fetal Leydig cells

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis KE Moderate

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

References