Difference between revisions of "Event:593"
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== How it is Measured or Detected == | == How it is Measured or Detected == | ||
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− | Generally, inhibition is mmeasured using patch clamp electrophysiology. There is also a commercially available hERG fluorescence polarization kit. </em> | + | Generally, inhibition is mmeasured using patch clamp electrophysiology. There is also a commercially available hERG fluorescence polarization kit. ToxCast assay NVS_IC_hKhERGCh also measures human ERG (hERG) inhibition. </em> |
== Evidence Supporting Taxonomic Applicability == | == Evidence Supporting Taxonomic Applicability == |
Revision as of 20:03, 5 June 2015
Contents
Event Title
Ether-a-go-go (ERG) voltage-gated potassium channel , Inhibition
Key Event Overview
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AOPs Including This Key Event
AOP Name | Event Type | Essentiality |
---|---|---|
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to increased predation | MIE | Strong |
Chemical Initiators
The following are chemical initiators that operate through this AOP:
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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Level of Biological Organization
Biological Organization |
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How this Key Event works
How it is Measured or Detected
Generally, inhibition is mmeasured using patch clamp electrophysiology. There is also a commercially available hERG fluorescence polarization kit. ToxCast assay NVS_IC_hKhERGCh also measures human ERG (hERG) inhibition.