Difference between revisions of "Event:593"

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(How it is Measured or Detected)
(How it is Measured or Detected)
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== How it is Measured or Detected ==
 
== How it is Measured or Detected ==
 
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<em>
Generally, inhibition is mmeasured using patch clamp electrophysiology.  There is also a commercially available hERG fluorescence polarization kit.  </em>
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Generally, inhibition is mmeasured using patch clamp electrophysiology.  There is also a commercially available hERG fluorescence polarization kit.  ToxCast assay NVS_IC_hKhERGCh also measures human ERG (hERG) inhibition.  </em>
  
 
== Evidence Supporting Taxonomic Applicability ==
 
== Evidence Supporting Taxonomic Applicability ==

Revision as of 20:03, 5 June 2015


Event Title

Ether-a-go-go (ERG) voltage-gated potassium channel , Inhibition

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to increased predation MIE Strong

Chemical Initiators

The following are chemical initiators that operate through this AOP:

  1. Chlorpromazine
  2. Verapamil
  3. Amiodarone

Taxonomic Applicability

Name Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

How it is Measured or Detected

Generally, inhibition is mmeasured using patch clamp electrophysiology. There is also a commercially available hERG fluorescence polarization kit. ToxCast assay NVS_IC_hKhERGCh also measures human ERG (hERG) inhibition.

Evidence Supporting Taxonomic Applicability

Evidence for Chemical Initiation of this Molecular Initiating Event

References