Difference between revisions of "Event:682"
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| rat || Rattus norvegicus || [[Event:682#Evidence Supporting Taxonomic Applicability|Strong]] || [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10116 NCBI] | | rat || Rattus norvegicus || [[Event:682#Evidence Supporting Taxonomic Applicability|Strong]] || [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10116 NCBI] | ||
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+ | | guinea pig || Cavia porcellus || [[Event:682#Evidence Supporting Taxonomic Applicability|Strong]] || [http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&id=10141 NCBI] | ||
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Revision as of 21:59, 21 July 2015
Contents
Event Title
Key Event Overview
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AOPs Including This Key Event
AOP Name | Event Type | Essentiality |
---|---|---|
Neurotoxicity induced by competitive antagonists of ionotropic GABA receptors | KE | Strong |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|---|---|---|
mouse | Mus musculus | Strong | NCBI |
rat | Rattus norvegicus | Strong | NCBI |
guinea pig | Cavia porcellus | Strong | NCBI |
Level of Biological Organization
Biological Organization |
---|
Tissue |
How this Key Event works
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the neuron more likely to fire an action potential. This temporary depolarization of postsynaptic membrane potential, as a result of opening ligand-gated ion channels, can be caused by the flow of positively charged ions into the postsynaptic cell, or a decrease in outgoing positive charges.
EPSPs are graded (i.e. they have an additive effect). When multiple EPSPs occur on a single patch of postsynaptic membrane, their combined effect is the sum of the individual EPSPs. Larger EPSPs result in greater membrane depolarization and thus increase the likelihood that the postsynaptic cell reaches the threshold for firing an action potential.
How it is Measured or Detected
EPSPs are usually recorded using intracellular electrodes. See Miura et al. (1997) and Bromfield et al. (2006) for details.
Evidence Supporting Taxonomic Applicability
See Dichter and Ayala (1987), Miura et al. (1997) and Bromfield et al. (2006) for relevant studies with supporting evidence.
References
Bromfield EB, Cavazos JE, Sirven JI. (2006) Chapter 1, Basic Mechanisms Underlying Seizures and Epilepsy. In: An Introduction to Epilepsy [Internet]. West Hartford (CT): American Epilepsy Society; Available from: http://www.ncbi.nlm.nih.gov/books/NBK2510/.
Dichter MA, Ayala GF. (1987) Cellular mechanisms of epilepsy: A status report. Science 237:157-164.
Miura M, Yoshioka M, Miyakawa H, Kato H, Ito KI. (1997) Properties of calcium spikes revealed during GABAA receptor antagonism in hippocampal CA1 neurons from guinea pigs. J Neurophysiol. 78(5):2269-79.