Event:682

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Event Title

Amplified excitatory postsynaptic potential (EPSP), Generation
Amplified EPSP, Generation

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Neurotoxicity induced by competitive antagonists of ionotropic GABA receptors KE Strong

Taxonomic Applicability

Name Scientific Name Evidence Links
mouse Mus musculus Strong NCBI
rat Rattus norvegicus Strong NCBI

Level of Biological Organization

Biological Organization
Tissue

How this Key Event works

In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the neuron more likely to fire an action potential. This temporary depolarization of postsynaptic membrane potential, as a result of opening ligand-gated ion channels, can be caused by the flow of positively charged ions into the postsynaptic cell, or a decrease in outgoing positive charges.

EPSPs are graded (i.e. they have an additive effect). When multiple EPSPs occur on a single patch of postsynaptic membrane, their combined effect is the sum of the individual EPSPs. Larger EPSPs result in greater membrane depolarization and thus increase the likelihood that the postsynaptic cell reaches the threshold for firing an action potential.

How it is Measured or Detected

Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?

Evidence Supporting Taxonomic Applicability

References