Event:78

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Event Title

Cumulative fecundity and spawning, Reduction
Short name: Cumulative fecundity and spawning, Reduction

Key Event Overview

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AOPs Including This Key Event

AOP Name Event Type Essentiality
Estrogen receptor agonism leading to reproductive dysfunction KE Strong
Aromatase inhibition leading to reproductive dysfunction KE Moderate
Androgen receptor agonism leading to reproductive dysfunction KE Moderate
Estrogen receptor antagonism leading to reproductive dysfunction KE Moderate
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation AO
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription AO

Taxonomic Applicability

Name Scientific Name Evidence Links

Affected Organs

Synonym Scientific Name Evidence Links

Level of Biological Organization

Biological Organization

How this Key Event works

Spawning refers to the release of eggs. Cumulative fecundity refers to the total number of eggs deposited by a female, or group of females over a specified period of time.

How it is Measured or Detected

In laboratory-based reproduction assays (e.g., OECD 229; OECD 240), spawning and cumulative fecundity can be directly measured through daily observation of egg deposition and egg counts.

Evidence Supporting Taxonomic Applicability

Cumulative fecundity and spawning can, in theory, be evaluated for any egg laying animal.

Regulatory Examples Using This Adverse Outcome

Cumulative fecundity is the most apical endpoint considered in the OECD 229 Fish Short Term Reproduction Assay. The OECD 229 assay serves as screening assay for endocrine disruption and associated reproductive impairment (OECD 2012). Fecundity is also an important apical endpoint in the Medaka Extended One Generation Reproduction Test (MEOGRT; OECD Test Guideline 240).

References

  • OECD. 2012a. Test no. 229: Fish short term reproduction assay. Paris, France:Organization for Economic Cooperation and Development.