Event:947
Contents
Event Title
Key Event Overview
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
AOPs Including This Key Event
AOP Name | Event Type | Essentiality |
---|---|---|
Aryl hydrocarbon receptor activation leading to embryolethality via cardiotoxicty | AO | [[Aop:150#Essentiality of the Key Events|]] |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
Affected Organs
Synonym | Scientific Name | Evidence | Links |
---|
Level of Biological Organization
Biological Organization |
---|
How this Key Event works
Embryo death at any stage in development prior to birth/hatch is considered embryolethal. In birds and fish it may be identified as failure to hatch or lack of movement within the egg when candled; heartbeat monitors are also available for identifying viable avian eggs. In mammals, stillborn or mummified offspring, or an increased rate of resorptions early in pregnancy are all considered embryolethal.
How it is Measured or Detected
Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?