Event:979
From AOP-Wiki
Contents
Event Title
Interference of NFAT complex formation at the site of nuclear cytokine promoters, Inhibition
Key Event Overview
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AOPs Including This Key Event
AOP Name | Event Type | Essentiality |
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The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression | AO | [[Aop:154#Essentiality of the Key Events|]] |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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Affected Organs
Synonym | Scientific Name | Evidence | Links |
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Level of Biological Organization
Biological Organization |
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How this Key Event works
How it is Measured or Detected
Methods that have been previously reviewed and approved by a recognized authority should be included in the Overview section above. All other methods, including those well established in the published literature, should be described here. Consider the following criteria when describing each method: 1. Is the assay fit for purpose? 2. Is the assay directly or indirectly (i.e. a surrogate) related to a key event relevant to the final adverse effect in question? 3. Is the assay repeatable? 4. Is the assay reproducible?