Event:985
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Contents
Event Title
Relief of atopic dermatitis, Relief
Key Event Overview
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AOPs Including This Key Event
AOP Name | Event Type | Essentiality |
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The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression | AO | [[Aop:154#Essentiality of the Key Events|]] |
Taxonomic Applicability
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Affected Organs
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Level of Biological Organization
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How this Key Event works
Patients with atopic dermatitis who were treated with FK506 ointment for a period of one year enjoyed relief from skin damage (FK506 Ointment Study Group. 1998). Generally, the skin of patients with atopic dermatitis has a higher expression of TLR-1 and a lower expression of TLR-2 than that of healthy subjects, but application of FK506 ointment suppressed expression of TLR-1 and increased expression of TLR-2 (Antiga et al. 2011).