Difference between revisions of "Relationship:1020"
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Revision as of 13:35, 15 May 2016
Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
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Suppression of cytokine production in the presence of T-cell activation, Suppression | Suppression of transplant rejection, Suppression |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
The Adverse Outcome Pathway on binding of FK506-binding protein 12 (FKBP12) by calcineurin inhibitors leading to immunosuppression | Indirectly Leads to | Moderate |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?