Difference between revisions of "Relationship:125"

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Include consideration of temporal concordance here
 
Include consideration of temporal concordance here
 
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Susceptibility to Thalidomide linked to the disruption of immature angiogenic network at time of exposure [Therapontos et al. 2009]. Predicted vascular disrupting chemicals in ToxCast correlate with developmental toxicity [Kleinstreuer et al. 2011].
  
 
=== Uncertainties or Inconsistencies ===
 
=== Uncertainties or Inconsistencies ===

Revision as of 16:59, 16 June 2016



Key Event Relationship Overview

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Description of Relationship

Upstream Event Downstream Event/Outcome
Endothelial network, Impairment Vascular, Insufficiency

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
VEGF Signaling and Vascular Disruption Leading to Adverse Developmental Outcomes Indirectly Leads to Moderate Weak

Taxonomic Applicability

Name Scientific Name Evidence Links

How Does This Key Event Relationship Work

In utero vascular disruptions are thought to be associated with a variety of developmental defects [Husain et al. 2008]. Vascular disruption was identified as one of 6 teratogenic mechanisms linked with medications [van Gelder et al. 2010].

Weight of Evidence

Biological Plausibility

In humans, the most common apparent cause of limb deficiencies was found to be vascular disruption defects [Gold et al. 2011]. Many genetic and environmental factors alter molecular pathways regulating angiogenesis [Knudsen and Kleinstreuer, 2011].

Empirical Support for Linkage

Include consideration of temporal concordance here

Susceptibility to Thalidomide linked to the disruption of immature angiogenic network at time of exposure [Therapontos et al. 2009]. Predicted vascular disrupting chemicals in ToxCast correlate with developmental toxicity [Kleinstreuer et al. 2011].

Uncertainties or Inconsistencies

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Evidence Supporting Taxonomic Applicability

References