Relationship:1276
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Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Neuron nerve ending excitation, Excitation | Trigeminal and/or vagal nerve excitation, Airway Hyper-responsiveness,Cough, Dyspnea |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Adverse outcome pathway for airway irritation and chemical sensitization | Directly Leads to | Strong | Strong |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Action potential propagation in afferent trigeminal and vagal nerves is widely known to mediate coughing, dyspnea, and other bodily reactions to irritation.
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
See Alarie (1973)for review of basic observations of the trigeminal nerves in irritation.
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?