Relationship:1276

From AOP-Wiki
Revision as of 19:20, 3 October 2016 by Jeanelli67 (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search


Key Event Relationship Overview

Please follow link to widget page to edit this section.

If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.

Description of Relationship

Upstream Event Downstream Event/Outcome
Neuron nerve ending excitation, Excitation Trigeminal and/or vagal nerve excitation, Airway Hyper-responsiveness,Cough, Dyspnea

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
Adverse outcome pathway for airway irritation and chemical sensitization Directly Leads to Strong Strong

Taxonomic Applicability

Name Scientific Name Evidence Links

How Does This Key Event Relationship Work

Action potential propagation in afferent trigeminal and vagal nerves is widely known to mediate coughing, dyspnea, and other bodily reactions to irritation.

Weight of Evidence

Biological Plausibility

Empirical Support for Linkage

See Alarie (1973)for review of basic observations of the trigeminal nerves in irritation.

Uncertainties or Inconsistencies

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Evidence Supporting Taxonomic Applicability

References