Difference between revisions of "Relationship:276"
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== Key Event Relationship Overview == | == Key Event Relationship Overview == | ||
[[Category:KE Relationship]] | [[Category:KE Relationship]] | ||
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=== Description of Relationship === | === Description of Relationship === |
Revision as of 17:30, 11 January 2015
Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Reactive oxygen species, Production | Oxidative Stress, Increase |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) | Directly Leads to | Very Strong |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
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How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?