Difference between revisions of "Relationship:276"
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!Upstream Event | !Upstream Event | ||
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!Downstream Event/Outcome | !Downstream Event/Outcome | ||
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− | |[[Reactive oxygen species, Production]] | + | |[[Reactive oxygen species, Production]]||[[Oxidative stress, Increase]] |
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!AOP Name | !AOP Name | ||
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!Weight of Evidence | !Weight of Evidence | ||
+ | !Quantitative Understanding | ||
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− | |[[Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)]]||Very Strong | + | |[[Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)]]||Leads to||Very Strong|| |
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|} | |} | ||
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+ | == How Does This Key Event Relationship Work == | ||
== Biological Plausibility == | == Biological Plausibility == |
Revision as of 00:36, 8 April 2014
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Contents
Key Event Relationship Overview
Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Reactive oxygen species, Production | Oxidative stress, Increase |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) | Leads to | Very Strong |
Taxonomic Applicability
<html> <button id="SpeciesList">Add Species from list</button> </html>
Common Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?