Relationship:276
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Contents
Key Event Relationship Overview
Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Reactive oxygen species, Production | Oxidative stress, Increase |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) | Directly Leads to | Very Strong |
Taxonomic Applicability
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Common Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?