Relationship:276

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Key Event Relationship Overview

Description of Relationship

Upstream Event Downstream Event/Outcome
Reactive oxygen species, Production Oxidative stress, Increase

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11) Directly Leads to Very Strong

Taxonomic Applicability

<html> <button id="SpeciesList">Add Species from list</button> </html>

Common Name Scientific Name Evidence Links

How Does This Key Event Relationship Work

Biological Plausibility

Empirical Support for Linkage

Include consideration of temporal concordance here

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Uncertainties or Inconsistencies

Evidence Supporting Taxonomic Applicability

References