Relationship:302

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Key Event Relationship Overview

Description of Relationship

Upstream Event Type of Relationship Downstream Event/Outcome
Testosterone synthesis by ovarian theca cells, Reduction Leads to 17beta-estradiol synthesis by overian granulosa cells, Reduction

AOPs Referencing Relationship

AOP Name Weight of Evidence
Androgen receptor agonism leading to reproductive dysfunction Not Specified

Taxonomic Applicability

<html> <button id="SpeciesList">Add Species from list</button> </html>

Common Name Scientific Name Evidence Links

Biological Plausibility

Empirical Support for Linkage

Include consideration of temporal concordance here

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Uncertainties or Inconsistencies

Evidence Supporting Taxonomic Applicability

References