Relationship:302
<html> <style> .ui-autocomplete {
max-height: 100px; overflow-y: auto; overflow-x: hidden; padding-right: 20px;
}
- html .ui-autocomplete {
height: 100px;
}
.ui-menu .ui-menu-item a
{ display: block; padding: 1px 1px 1px 1px; text-decoration: none; cursor: pointer; font-size: 13px; }
</style>
<link type='text/css' rel='stylesheet' href='/extensions/jquery-ui-1.9.2/themes/base/jquery-ui.css'> <script type="text/javascript" src="/extensions/jquery-ui-1.9.2/ui/jquery-ui.js"></script> <script type="text/javascript" src="/extensions/EPA/Upstream_Key_Event.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Species.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Chemicals.js"></script> <script type="text/javascript" src="/extensions/EPA/MOA_Key_Event.js"></script> </html>
Contents
Key Event Relationship Overview
Description of Relationship
Upstream Event | Type of Relationship | Downstream Event/Outcome |
---|---|---|
Testosterone synthesis by ovarian theca cells, Reduction | Leads to | 17beta-estradiol synthesis by overian granulosa cells, Reduction |
AOPs Referencing Relationship
AOP Name | Weight of Evidence |
---|---|
Androgen receptor agonism leading to reproductive dysfunction | Not Specified |
Taxonomic Applicability
<html> <button id="SpeciesList">Add Species from list</button> </html>
Common Name | Scientific Name | Evidence | Links |
---|
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?