Difference between revisions of "Relationship:635"

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Latest revision as of 02:41, 28 November 2016


Key Event Relationship Overview

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Description of Relationship

Upstream Event Downstream Event/Outcome
5-hydroxytryptamine transporter (5-HTT; SERT), Inhibition serotonin (5-HT), Increased

AOPs Referencing Relationship

AOP Name Type of Relationship Weight of Evidence Quantitative Understanding
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline Directly Leads to

Taxonomic Applicability

Name Scientific Name Evidence Links

How Does This Key Event Relationship Work

Inhibition of the reuptake of serotonin results in increased residence time and activity of serotonin in synapses.

Weight of Evidence

Biological Plausibility

Empirical Support for Linkage

Include consideration of temporal concordance here

Uncertainties or Inconsistencies

Quantitative Understanding of the Linkage

Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?

Evidence Supporting Taxonomic Applicability

References