Difference between revisions of "Relationship:785"
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== How Does This Key Event Relationship Work == | == How Does This Key Event Relationship Work == | ||
+ | Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia. | ||
== Weight of Evidence == | == Weight of Evidence == |
Revision as of 17:22, 26 August 2015
Contents
Key Event Relationship Overview
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Description of Relationship
Upstream Event | Downstream Event/Outcome |
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Regenerative cell proliferation (tubular epithelial cells), Increase | Hyperplasia (tubular epithelial cells), Increase |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) | Directly Leads to |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia.
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?