Difference between revisions of "Relationship:785"
From AOP-Wiki
(Created page with "__ForceTOC__ == Key Event Relationship Overview == Category:KE Relationship Please follow link to [//{{SERVERNAME}}/aopportal/relationships/{{PAGENAMEE}} widget page] to...") |
(unknown rel user updated summary tables from widget page.) |
||
(3 intermediate revisions by 2 users not shown) | |||
Line 3: | Line 3: | ||
== Key Event Relationship Overview == | == Key Event Relationship Overview == | ||
[[Category:KE Relationship]] | [[Category:KE Relationship]] | ||
− | Please follow link to [//{{SERVERNAME}} | + | Please follow link to [//{{SERVERNAME}}/relationships/{{PAGENAMEE}} widget page] to edit this section. |
+ | |||
+ | <span style="color:#FF0000">'''If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.'''</span> | ||
=== Description of Relationship === | === Description of Relationship === | ||
Line 10: | Line 12: | ||
!Upstream Event | !Upstream Event | ||
!Downstream Event/Outcome | !Downstream Event/Outcome | ||
+ | |||
+ | |- | ||
+ | |||
+ | |[[Event:710|Regenerative cell proliferation (tubular epithelial cells), Increase]]||[[Event:784|Hyperplasia (tubular epithelial cells), Increase]] | ||
|- | |- | ||
Line 22: | Line 28: | ||
!Weight of Evidence | !Weight of Evidence | ||
!Quantitative Understanding | !Quantitative Understanding | ||
+ | |||
+ | |- | ||
+ | |||
+ | |[[Aop:116|Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) ]]||Directly Leads to|||| | ||
|- | |- | ||
Line 41: | Line 51: | ||
== How Does This Key Event Relationship Work == | == How Does This Key Event Relationship Work == | ||
+ | Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia. | ||
== Weight of Evidence == | == Weight of Evidence == |
Latest revision as of 04:06, 17 January 2016
Contents
Key Event Relationship Overview
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
Regenerative cell proliferation (tubular epithelial cells), Increase | Hyperplasia (tubular epithelial cells), Increase |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat) | Directly Leads to |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Sustained regenerative cell proliferation directly leads to renal tubular hyperplasia.
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?