Difference between revisions of "Relationship:9"
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== Key Event Relationship Overview == | == Key Event Relationship Overview == | ||
[[Category:KE Relationship]] | [[Category:KE Relationship]] | ||
+ | Please follow link to [//{{SERVERNAME}}/relationships/{{PAGENAMEE}} widget page] to edit this section. | ||
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+ | <span style="color:#FF0000">'''If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.'''</span> | ||
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=== Description of Relationship === | === Description of Relationship === | ||
{| class="wikitable sortable" id="relation" | {| class="wikitable sortable" id="relation" | ||
!Upstream Event | !Upstream Event | ||
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!Downstream Event/Outcome | !Downstream Event/Outcome | ||
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− | |[[3-hydroxyacyl-CoA dehydrogenase type-2 activity, Decreased]] | + | |[[Event:8|3-hydroxyacyl-CoA dehydrogenase type-2 activity, Decreased]]||[[Event:179|Mitochondrial fatty acid beta-oxidation, Decreased]] |
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!AOP Name | !AOP Name | ||
+ | !Type of Relationship | ||
!Weight of Evidence | !Weight of Evidence | ||
+ | !Quantitative Understanding | ||
|- | |- | ||
− | |[[Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis]]||Strong | + | |[[Aop:36|Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis]]||Directly Leads to||[[Relationship:9#Weight of Evidence|Strong]]|| |
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=== Taxonomic Applicability === | === Taxonomic Applicability === | ||
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{|class="wikitable sortable" id="Specproof" | {|class="wikitable sortable" id="Specproof" | ||
− | ! | + | !Name |
!Scientific Name | !Scientific Name | ||
!Evidence | !Evidence | ||
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|} | |} | ||
− | == | + | == How Does This Key Event Relationship Work == |
− | == Empirical Support for Linkage == | + | == Weight of Evidence == |
+ | === Biological Plausibility === | ||
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+ | === Empirical Support for Linkage === | ||
* People with the G1528C mutation in HSD17B10 gene exhibit hepatomegaly and steatosis <ref>Tyni T1, Rapola J, Paetau A, Palotie A, Pihko H. 1997. Pathology of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation. Pediatr Pathol Lab Med 17(3):427-47.</ref>. | * People with the G1528C mutation in HSD17B10 gene exhibit hepatomegaly and steatosis <ref>Tyni T1, Rapola J, Paetau A, Palotie A, Pihko H. 1997. Pathology of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation. Pediatr Pathol Lab Med 17(3):427-47.</ref>. | ||
* Post mortem analyses of livers from children who died prior to 1 year of age demonstrated a link between steatosis \and 3-hydroxyacyl-CoA dehydrogenase activity <ref>Boles RG1, Buck EA, Blitzer MG, Platt MS, Cowan TM, Martin SK, Yoon H, Madsen JA, Reyes-Mugica M, Rinaldo P. 1998. Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life. J Pediatr 132(6):924-33.</ref>. | * Post mortem analyses of livers from children who died prior to 1 year of age demonstrated a link between steatosis \and 3-hydroxyacyl-CoA dehydrogenase activity <ref>Boles RG1, Buck EA, Blitzer MG, Platt MS, Cowan TM, Martin SK, Yoon H, Madsen JA, Reyes-Mugica M, Rinaldo P. 1998. Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life. J Pediatr 132(6):924-33.</ref>. | ||
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+ | === Uncertainties or Inconsistencies === | ||
== Quantitative Understanding of the Linkage == | == Quantitative Understanding of the Linkage == | ||
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Are there models or extrapolation approaches that help describe those relationships? | Are there models or extrapolation approaches that help describe those relationships? | ||
</em> | </em> | ||
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== Evidence Supporting Taxonomic Applicability == | == Evidence Supporting Taxonomic Applicability == |
Latest revision as of 03:58, 17 January 2016
Contents
Key Event Relationship Overview
Please follow link to widget page to edit this section.
If you manually enter text in this section, it will get automatically altered or deleted in subsequent edits using the widgets.
Description of Relationship
Upstream Event | Downstream Event/Outcome |
---|---|
3-hydroxyacyl-CoA dehydrogenase type-2 activity, Decreased | Mitochondrial fatty acid beta-oxidation, Decreased |
AOPs Referencing Relationship
AOP Name | Type of Relationship | Weight of Evidence | Quantitative Understanding |
---|---|---|---|
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis | Directly Leads to | Strong |
Taxonomic Applicability
Name | Scientific Name | Evidence | Links |
---|
How Does This Key Event Relationship Work
Weight of Evidence
Biological Plausibility
Empirical Support for Linkage
- People with the G1528C mutation in HSD17B10 gene exhibit hepatomegaly and steatosis [1].
- Post mortem analyses of livers from children who died prior to 1 year of age demonstrated a link between steatosis \and 3-hydroxyacyl-CoA dehydrogenase activity [2].
Uncertainties or Inconsistencies
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?
Evidence Supporting Taxonomic Applicability
References
- ↑ Tyni T1, Rapola J, Paetau A, Palotie A, Pihko H. 1997. Pathology of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency caused by the G1528C mutation. Pediatr Pathol Lab Med 17(3):427-47.
- ↑ Boles RG1, Buck EA, Blitzer MG, Platt MS, Cowan TM, Martin SK, Yoon H, Madsen JA, Reyes-Mugica M, Rinaldo P. 1998. Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life. J Pediatr 132(6):924-33.