Relationship:9
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Contents
Key Event Relationship Overview
Description of Relationship
Upstream Event | Type of Relationship | Downstream Event/Outcome |
---|---|---|
3-hydroxyacyl-CoA dehydrogenase type-2 activity, Decreased | Leads to | Mitochondrial fatty acid beta-oxidation, Decreased |
AOPs Referencing Relationship
AOP Name | Weight of Evidence |
---|---|
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis | Strong |
Taxonomic Applicability
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Common Name | Scientific Name | Evidence | Links |
---|
Biological Plausibility
Empirical Support for Linkage
Include consideration of temporal concordance here
Quantitative Understanding of the Linkage
Is it known how much change in the first event is needed to impact the second? Are there known modulators of the response-response relationships? Are there models or extrapolation approaches that help describe those relationships?